PCSO-524™ has unique polyunsaturated fatty acids (PUFAs) 4,5; including 5,9,12,15-octodecatetraenoic acid (OTA), 5,9,12,16-nonadecatertraenoic acid, 7,11,14,17-eicosatetraenoic acid (ETA), and 5,9,12,15,18-heneicosapentaenoic acid 4. These molecules (including EPA and DHA) are similar to arachidonic acid (AA) (5,8,11,14-eicosatetraenoic acid), the precursor to the inflammatory agents, prostaglandins and leukotrienes. In case of ETA the first double bond is located at the seventh position, and the second double bond is interrupted from the first by two methylene groups, resulting in the double bonds at positions 7, 11, 14 and 17.
Bioavailability of krill oil has been suggested to be higher than fish oil as much of the EPA and DHA in krill oil are bound to phospholipids. A recent study in humans found that krill oil improved the subjective symptoms of knee pain in adults with mild knee pain (23). EAB-277 is a combination of phospholipids extracted from krill oil together with lipid fractions from the Green Lipped Mussel. Two patients from Group B were excluded because of https://pcso.online/ adverse effects of the fish oil (diarrhea, nausea, stomach aches, increased arterial blood pressure). After they finished stage I, all 22 patients from Group B continued the study under the same protocol as the PCSO-524™ Group A patients and then formed Group C (stage II).
History of PCSO:
The relatively short duration of treatments is certainly a limitation of the study. To our knowledge, this was the first clinical trial of EAB-277 nutraceutical in OA dogs. The main difference between EAB-277 from PCSO-524 is that it contains with high concentrations of phospholipids extracted from Euphausia superba in addition to the components of PCSO4-524. The clinical laboratory values of all dogs were within normal limits during the study period of 6 weeks.
In 1954, Republic Act 1169 was enacted, which mandating the establishment of monthly charity sweepstakes and regular lottery games. The PCSO is focused on generating recurring and permanent income through its various operations, such as charitable sweepstakes and races. It also invests in projects and activities that are related to the welfare and health of its members. Whether through financial support for health programs or active engagement in community services, Philippine Charity Sweepstakes Office continues to be a vital contributor to the social welfare of the nation.
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Patients often use well-known analgesics such as paracetamol or ibuprofen to treat pain related to OA. Long-term intake of these analgesics may cause gastro-intestinal side effects and might also adversely affect the kidneys. PCSO-524™ has been shown to be an effective complementary or alternative active ingredient for the treatment of OA without any side effects 3.
Our result is also similar to another OA study (22) using the NSAID treatment firocoxib where the change in PVF of the index limb was reported to be 3.03 ± 4.67 and 3.25 ± 4.13 at 2 and 4 weeks treatment, respectively. However, all these values are lower than the 5%−10% change discussed in the literature as being “unlikely to have occurred by chance” (32, 33). Those data and conclusions were drawn based on treatment of cruciate ligament disease, and these may not be relevant to a situation where one is assessing the change in limb use in dogs with bilateral OA. While further research needs to be done to ascertain what a meaningful change in PVF would be in dogs with bilateral OA, we believe that the change seen in the PCSO-524, EAB-277, and carprofen groups is clinically meaningful. Indeed, the standardized effect size (SES) for PCSO4-524 was 1.1 at 6 weeks.
- The OAS system was originally described by Moreau et al. (5) and adapted by McCarthy et al. (15).
- In 1992, President Ramos issued a proclamation asking the commercial and public sectors to support the PCSO’s special Pinatubo lottery draw, which would help raise funds for the victims of the eruption.
- This program also helps address the health and welfare needs of the communities.
- PCSO Gift Check Validation – The PCSO Gift Check is a monetary assistance program that provides financial aid to those who have been diagnosed with a terminal illness.
- The prize pool will be carried over to the next drawing if no one wins the first reward.
The evolution of PCSO’s fundraising activities, from traditional charity sweepstakes to innovative lotteries and gaming ventures, reflects its adaptability to societal needs. Of topics such as lottery results, game mechanics, draw schedules, claiming prizes, and different charity programs and initiatives. By partnering with private companies and other entities, the PCSO ensures a diversified and robust funding stream that can support its charitable programs effectively and efficiently.
The agency’s first innovation was the creation of the Instant Sweepstakes, which was modeled after a similar game that was conducted in the US. By the end of the year, the program had already contributed over 27 million to the PCSO Charity Fund. For over half a century, the PCSO has been relying on the traditional sweepstakes as its primary source of funding. Beyond gaming activities, Philippine Charity Sweepstakes Office has diversified its services to include free medical and dental care, disaster response, and active participation in community outreach. The Philippine Charity Sweepstakes Office has introduced new lotteries and expanded its services beyond gaming activities. Innovations like Instant Sweepstakes, Small Town Lottery (STL), and Lotto in 1995 marked significant milestones.
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